P3.03-018 Suppression of Tumor Growth by Pegylated Arginase in Malignant Pleural Mesothelioma
نویسندگان
چکیده
منابع مشابه
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts
BACKGROUND Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma. This study aims to investigate the effects of PEG-BCT-100 in MPM. METHODS A panel of 5 mesothelioma cell lines (H28, 211H, H226, H2052 and H2452) was used to study the in vit...
متن کامل[Malignant pleural mesothelioma].
Overview Mesothelioma is a rare cancer that is estimated to occur in approximately 2500 people in the United States every year.1,2 These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on malignant pleural mesothelioma (MPM), which is the most common type; mesothelioma can also occur in other sites (e.g., peritoneum, pericardium, tunica vaginalis testis). The disease is di...
متن کاملMalignant pleural mesothelioma.
Malignant pleural mesotheliomas are tumors originating in the serosal lining of the pleural cavities. Although these are relatively rare tumors, an increasing number of cases are anticipated over the next decade. Patients with these tumors, which are almost invariably fatal, usually have an interval of less than two years between the onset of symptoms and death. There is a well established link...
متن کاملMalignant pleural mesothelioma.
malignant pleural mesothelioma is a relatively uncommon disease associated with asbestos exposure. its incidence increased markedly following the widespread mining and use of asbestos in many industries. the legal aspects regarding compensation cases for those who have developed this disease has raised its profile in the media, but also compounds the stress of diagnosis for patients. it has an ...
متن کاملDiagnosing malignant pleural mesothelioma.
The diagnosis of malignant pleural mesothelioma is a difficult clinical task. A suspicion of mesothelioma should always arise, when a patient with a case history of reasonable asbestos exposure is examined for pleural effusion or pleural masses of unknown aetiology [1]. In addition to asbestos exposure a heredilory predisposing factor has been suggested to be of importance for the development o...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.1917